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Maintenance of the blood pressure effect over the 24-hour dosing interval was observed, with little difference in peak and trough effect. Tolerance was not demonstrated in patients studied for up to 1 year. Nifedipine. Adalat, Procardia.

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Clinical data
Pronunciation/ æ m ˈ l oʊ d ɪ ˌ p iː n / [1]
Trade namesNorvasc, others
License dataEU  EMA:  by INN, US  DailyMed:  Amlodipine, US   FDA: Amlodipine
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classCalcium channel blocker
ATC codeC08CA01 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding93% [2]
MetabolitesVarious inactive pyrimidine metabolites
Onset of actionHighest availability 6–12 hours after oral dose
Elimination half-life30–50 hours
Duration of actionAt least 24 hours

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In general, wait 7 to 14 days between titration steps.Based on the association between SBP at hypertensive visit and the required dose, the proposed starting dose for cats with a SBP 200 mmHg would be 1.

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With norvasc 5mg tablet once daily oral administration, antihypertensive effectiveness is maintained for at least 24 hours. Plasma concentrations correlate with effect in both young and elderly patients.Do not share this medication with others.


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