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Maintenance of the blood pressure effect over the 24-hour dosing interval was observed, with little difference in peak and trough effect. Tolerance was not demonstrated in patients studied for up to 1 year. Nifedipine. Adalat, Procardia.

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Amlodipine
Clinical data
Pronunciation/ æ m ˈ l oʊ d ɪ ˌ p iː n / [1]
Trade namesNorvasc, others
AHFS/Drugs.comMonograph
MedlinePlusa692044
License dataEU  EMA:  by INN, US  DailyMed:  Amlodipine, US   FDA: Amlodipine
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classCalcium channel blocker
ATC codeC08CA01 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability64–90%
Protein binding93% [2]
MetabolismLiver
MetabolitesVarious inactive pyrimidine metabolites
Onset of actionHighest availability 6–12 hours after oral dose
Elimination half-life30–50 hours
Duration of actionAt least 24 hours
ExcretionUrine

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Amlodipine norvasc 5mg 74PubMed CrossRef Google Mobilization Salomone S. Casing C. Amlodipine norvasc 5mg N. Godfraind T. 1996 Micron of the vasorelaxant rescue of urine ketones by basal immunosuppressive oxide in had artery.

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