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J. Neurol.The MAO-B inhibitors can increase serotonin levels through their ability to inhibit its metabolism and subsequent activation of 5-hydroxytryptamine 5HT receptors. This can increase the risk of serotonin syndrome when used at higher doses and in various combinations.
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What enzyme breaks down selegiline?
See Drug Interactions.No cases of hypertensive crisis were reported in any of the controlled clinical trials.
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