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Since cross reactivity, including bronchospasm, between aspirin and other nonsteroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, nabumetone should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma - click to see more.
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Although serious GI tract ulcerations and bleeding can occur without warning symptoms, patients should be alert for the signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing any indicative sign or symptoms including epigastric pain, dyspepsia, melena, and hematemesis.Nabumetone Active Metabolite 6MNA Plasma Concentrations at Steady State Following Once-Daily Dosing of Nabumetone 6MNA undergoes biotransformation in the liver, producing inactive metabolites that are eliminated as both free metabolites and conjugates.
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Talk to your doctor if you are using marijuana cannabis This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding.Patients with a history of GI peptic disease, particularly when elderly, should be alerted to report any unusual abdominal symptoms indicative for ulceration especially GI bleeding particularly in the initial stages of treatment.
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Most NSAIDs have been associated with an increased risk of stroke or heart attack. The risk may be higher for patients with pre-existing conditions, in those who drink more than three glasses of alcohol per day, and with higher dosages.NSAIAs are contraindicated in the setting of coronary artery bypass graft CABG surgery. Patients should be advised to read the medication guide for NSAIAs that is provided to the patient each time the drug is dispensed.
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