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Isotretinoin
Clinical data
PronunciationSee note at tretinoin
Trade namesAccutane (originator), others [1]
AHFS/Drugs.comMonograph
MedlinePlusa681043
License dataUS   FDA: Isotretinoin
Pregnancy categoryAU: X (High risk) US: X (Contraindicated)
Routes of administrationBy mouth, topical
ATC codeD10AD04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityVariable
Protein binding99.9%
MetabolismHepatic
Elimination half-life10–20 hours
ExcretionRenal and fecal

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Sotret synonym drug:
  • Accuran 20 mg
  • Accutin 30 mg
  • Acnecutan 5 mg
  • Acnemin 30 mg
  • Acnetane 20 mg
  • Acnetrex 30 mg
  • Acnil 10 mg
  • Acnogen 40 mg
  • Acnotin 5 mg
  • Aisoskin 30 mg
  • Aknenormin 30 mg
  • Aknesil 30 mg
  • Amnesteem 40 mg
  • Antibiotrex 10 mg
  • Atlacne 5 mg
  • Ciscutan 5 mg
  • Claravis 20 mg
  • Clarus 20 mg
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Sotret instruction
Drug name Sotret
Sotret alternativesaccuran, accutin, acnecutan, acnemin, acnetane, acnetrex, acnil, acnogen, acnotin, aisoskin, aknenormin, aknesil, amnesteem, antibiotrex, atlacne, ciscutan, claravis, clarus, curacne, curakne, curatane, cuticilin, decutan, dercutane, farmacne, flexresan, flitrion, inotrin, isdiben, isoacne, isocural, isoderm, isodermal, isoface, isogalen, isogeril, isoprotil, isoriac, isoskin, isosuppra, isosupra lidose, isotane, isotret, isotret-hexal, isotretin, isotretinoina, isotretinoinum, isotrex, isotrexin, isotroin, izotek, lurantal, lyotret, neotrex, nimegen, noitron, noroseptan, novacne, opridan, oratane, piplex, policano, procuta, retinide, retnol, roaccutan, roaccutane, roacnetan, roacutan, sotret, stiefotrex, trecifan, tretinac, tretinak, tretinex, zonatian, zoretanin
Active substancesisotretinoin
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These accutane types are more frequent for female patients who use only a single method of contraception. Therefore, it is critically important that female patients of childbearing potential use 2 effective forms of contraception simultaneously.8 of pediatric patients.

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This drug debuted in 1982 as Accutane, but that accutane type name was discontinued by manufacturer Roche Holding AG in June 2009. Isotretinoin works by accutane type the oil, or sebaceous, glands in the skin.You must watch a videotape on contraceptive methods and completely abstain from sexual intercourse or practice 2 forms of birth control beginning 1 month before, during, and for 1 month after use of Sotret.

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At first, juries ordered Roche to pay millions to patients, but judges overturned those verdicts.Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe accutane type reaction fever, sore throat, accutane type eyes, skin pain, red or purple skin rash with blistering and peeling symptoms of depression--unusual mood changes, crying spells, feelings of low self-worth, loss of interest in things you once enjoyed, new sleep problems, thoughts about hurting yourself; signs of liver or pancreas problems--loss of appetite, upper stomach pain that may accutane type to your back nausea or vomiting, accutane type heart rate, dark urine, jaundice yellowing of the skin or eyes severe stomach problems--severe stomach or chest pain, pain when swallowing, heartburn, diarrhea, rectal bleeding, bloody sotret availability tarry stools; or increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

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